In order to avoid confusion, it is best if you followed a systematic way of combining things. There are so many item combinations possible that it is easy lose track of which materials have already been combined. It’s a good thing you can rely on our Little Alchemy 2 guide for unlocking all the items! 1. There are over 600 items to create so don’t underestimate the difficulty of this game. The items you unlock will appear in the encyclopedia which you can check out to see the quirky descriptions the developers have come up with. Every time you create a new item, it will be added to the list of materials that you can use to make even more things. You start off with just the four basic elements: Earth, Fire, Air, and Water. You just need to combine different items in order to create new ones. After the huge success of its predecessor, Little Alchemy 2 comes to iOS and Android devices with shiny new visuals and an entire new library to fill with items.